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Tofacitinib 杂质 28 CAS号 2227199-31-5

基本信息

CAS(化学文摘登记)号

2227199-31-5

英文名称

Tofacitinib 杂质 28

英文化学名

Butyl3-[(3R,4R)-4-methyl-3-[methyl({7Hpyrrolo[2,3-d]pyrimidin-4-yl})amino]piperidin-1-yl]-3-oxopropanoate

简化分子线性输入规范(SMILES)

O=C(OCCCC)CC(N1C[C@H](N(C)C2=C3C(NC=C3)=NC=N2)[C@H](C)CC1)=O

分子式

C20H29N5O3

分子量

387.5

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Tofacitinib Impurity 28 is chemically Butyl3-[(3R,4R)-4-methyl-3-[methyl({7Hpyrrolo[2,3-d]pyrimidin-4-yl})amino]piperidin-1-yl]-3-oxopropanoate. Tofacitinib Impurity 28 is supplied with detailed characterization data compliant with regulatory guideline. Tofacitinib Impurity 28 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tofacitinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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邮箱：chemwhat@watson-int.cn

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ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/tofacitinib-impurity-28-cas-2227199-31-5/

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Tofacitinib 杂质 30 CAS号 105-56-6

基本信息

CAS(化学文摘登记)号

105-56-6

英文名称

Tofacitinib 杂质 30

英文化学名

Ethyl cyanoacetate

简化分子线性输入规范(SMILES)

O=C(OCC)CC#N

分子式

C5H7NO2

分子量

113.1

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Tofacitinib Impurity 30 is chemically Ethyl cyanoacetate. Tofacitinib Impurity 30 is supplied with detailed characterization data compliant with regulatory guideline. Tofacitinib Impurity 30 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tofacitinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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邮箱：chemwhat@watson-int.cn

品牌

ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/tofacitinib-impurity-30-cas-105-56-6/

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Tofacitinib 杂质 64 CAS号 N/A

基本信息

CAS(化学文摘登记)号

N/A

英文名称

Tofacitinib 杂质 64

英文化学名

Ethyl 4-cyano-3-imino-5-((3S,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-5-oxopentanoate

简化分子线性输入规范(SMILES)

CCOC(CC(C(C#N)C(N1CC[C@H](C)[C@H](N(C2=C(C=CN3)C3=NC=N2)C)C1)=O)=N)=O

分子式

C21H27N7O3

分子量

425.5

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Tofacitinib Impurity 64 is chemically Ethyl 4-cyano-3-imino-5-((3S,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-5-oxopentanoate. Tofacitinib Impurity 64 is supplied with detailed characterization data compliant with regulatory guideline. Tofacitinib Impurity 64 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tofacitinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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邮箱：chemwhat@watson-int.cn

品牌

ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/tofacitinib-related-substance-9-cas-N/A/

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Tofacitinib 杂质 66 CAS号 N/A

基本信息

CAS(化学文摘登记)号

N/A

英文名称

Tofacitinib 杂质 66

英文化学名

3-((3S,4S)-3-((2-Chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile

简化分子线性输入规范(SMILES)

ClC1=NC(N(C)[C@H]2[C@@H](C)CCN(C(CC#N)=O)C2)=C(C=CN3)C3=N1

分子式

C16H19ClN6O

分子量

346.8

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Tofacitinib Impurity 66 is chemically 3-((3S,4S)-3-((2-Chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile. Tofacitinib Impurity 66 is supplied with detailed characterization data compliant with regulatory guideline. Tofacitinib Impurity 66 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tofacitinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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邮箱：chemwhat@watson-int.cn

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ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/tofacitinib-related-substance-11-cas-N/A/

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Tofacitinib 杂质 35 CAS号 2101958-24-9

基本信息

CAS(化学文摘登记)号

2101958-24-9

英文名称

Tofacitinib 杂质 35

英文化学名

3-((3R,4R)-3-(((5R,6S)-5,6-Dihydroxy-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile

简化分子线性输入规范(SMILES)

O[C@@H]1C2=C(N([C@H]3CN(C(CC#N)=O)CC[C@H]3C)C)N=CN=C2N[C@H]1O

分子式

C16H22N6O3

分子量

346.4

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Tofacitinib Impurity 35 is chemically 3-((3R,4R)-3-(((5R,6S)-5,6-Dihydroxy-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile. Tofacitinib Impurity 35 is supplied with detailed characterization data compliant with regulatory guideline. Tofacitinib Impurity 35 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tofacitinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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邮箱：chemwhat@watson-int.cn

品牌

ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/tofacitinib-related-substance-1-cas-2101958-24-9/

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Tofacitinib 杂质 60 CAS号 N/A

基本信息

CAS(化学文摘登记)号

N/A

英文名称

Tofacitinib 杂质 60

英文化学名

3-((3R,4R)-3-(((5R,6S)-2-Hydroxy-5,6-dimethyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile

简化分子线性输入规范(SMILES)

OC1=NC2=C([C@@H](C)[C@H](C)N2)C(N(C)[C@H]3CN(C(CC#N)=O)CC[C@H]3C)=N1

分子式

C18H26N6O2

分子量

358.4

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Tofacitinib Impurity 60 is chemically 3-((3R,4R)-3-(((5R,6S)-2-Hydroxy-5,6-dimethyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)(methyl)amino)-4-methylpiperidin-1-yl)-3-oxopropanenitrile. Tofacitinib Impurity 60 is supplied with detailed characterization data compliant with regulatory guideline. Tofacitinib Impurity 60 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tofacitinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

快速询价

邮箱：chemwhat@watson-int.cn

品牌

ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/tofacitinib-related-substance-4-cas-N/A/

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Tofacitinib 杂质 27 CAS号 N/A

基本信息

CAS(化学文摘登记)号

N/A

英文名称

Tofacitinib 杂质 27

英文化学名

Butyl (2E)-3-amino-2-methyl-5-[(3R,4R)-4-methyl-3-[methyl({7H-pyrrolo[2,3-d]pyrimidin-4-yl})amino]piperidin-1-yl]-5-oxopent-2-enoate

简化分子线性输入规范(SMILES)

O=C(OCCCC)/C(C)=C(N)CC(N1C[C@H](N(C)C2=C3C(NC=C3)=NC=N2)[C@H](C)CC1)=O

分子式

C23H34N6O3

分子量

442.6

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Tofacitinib Impurity 27 is chemically Butyl (2E)-3-amino-2-methyl-5-[(3R,4R)-4-methyl-3-[methyl({7H-pyrrolo[2,3-d]pyrimidin-4-yl})amino]piperidin-1-yl]-5-oxopent-2-enoate. Tofacitinib Impurity 27 is supplied with detailed characterization data compliant with regulatory guideline. Tofacitinib Impurity 27 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tofacitinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

快速询价

邮箱：chemwhat@watson-int.cn

品牌

ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/tofacitinib-impurity-27-cas-N/A/

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Tofacitinib 杂质 4 CAS号 1675248-18-6

基本信息

CAS(化学文摘登记)号

1675248-18-6

英文名称

Tofacitinib 杂质 4

英文化学名

Ethyl 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanoate

简化分子线性输入规范(SMILES)

CN([C@H]([C@@H](CC1)C)CN1C(CC(OCC)=O)=O)C2=C(C=CN3)C3=NC=N2

分子式

C18H25N5O3

分子量

359.4

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Tofacitinib Impurity 4 is chemically Ethyl 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanoate. It is also known as 2-Descyano-2-ethyl Formyl-tofacitinib. Tofacitinib Impurity 4 is supplied with detailed characterization data compliant with regulatory guideline. Tofacitinib Impurity 4 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tofacitinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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邮箱：chemwhat@watson-int.cn

品牌

ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/tofacitinib-impurity-4-cas-1675248-18-6/

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Tofacitinib 杂质 34 CAS号 1111638-10-8

基本信息

CAS(化学文摘登记)号

1111638-10-8

英文名称

Tofacitinib 杂质 34

英文化学名

6-chloro-1H-imidazo[4,5-b]pyrazine

简化分子线性输入规范(SMILES)

ClC1=CN=C2C(NC=N2)=N1

分子式

C5H3ClN4

分子量

154.6

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Tofacitinib Impurity 34 is chemically 6-chloro-1H-imidazo[4,5-b]pyrazine. Tofacitinib Impurity 34 is supplied with detailed characterization data compliant with regulatory guideline. Tofacitinib Impurity 34 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tofacitinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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邮箱：chemwhat@watson-int.cn

品牌

ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/tofacitinib-impurity-34-cas-1111638-10-8/

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Tofacitinib 杂质 65 CAS号 N/A

基本信息

CAS(化学文摘登记)号

N/A

英文名称

Tofacitinib 杂质 65

英文化学名

3-Imino-5-((3S,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-2-((3S,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carbonyl)-5-oxopentanenitrile

简化分子线性输入规范(SMILES)

C[C@H]([C@H](N(C)C1=NC=NC2=C1C=CN2)C3)CCN3C(C(C#N)C(CC(N4CC[C@H](C)[C@H](N(C5=C(C=CN6)C6=NC=N5)C)C4)=O)=N)=O

分子式

C32H40N12O2

分子量

624.8

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Tofacitinib Impurity 65 is chemically 3-Imino-5-((3S,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-2-((3S,4S)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carbonyl)-5-oxopentanenitrile. Tofacitinib Impurity 65 is supplied with detailed characterization data compliant with regulatory guideline. Tofacitinib Impurity 65 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Tofacitinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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邮箱：chemwhat@watson-int.cn

品牌

ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/tofacitinib-related-substance-10-cas-N/A/

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