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Dolutegravir 杂质 32 CAS号 N/A

基本信息

CAS(化学文摘登记)号

N/A

英文名称

Dolutegravir 杂质 32

英文化学名

(4S,12aR)-N-(2,4-Difluorobenzyl)-7-methoxy-4,12a-dimethyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide

简化分子线性输入规范(SMILES)

FC1=CC=C(CNC(C2=CN(C[C@]3(C)N([C@@H](C)CCO3)C4=O)C4=C(OC)C2=O)=O)C(F)=C1

分子式

C22H23F2N3O5

分子量

447.4

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Dolutegravir Impurity 32 is chemically (4S,12aR)-N-(2,4-Difluorobenzyl)-7-methoxy-4,12a-dimethyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide. Dolutegravir Impurity 32 is supplied with detailed characterization data compliant with regulatory guideline. Dolutegravir Impurity 32 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Dolutegravir. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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ChemWhat（凯望）—— 品牌介绍

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Dolutegravir O-beta-D-Glucuronide CAS号 1485692-21-4

基本信息

CAS(化学文摘登记)号

1485692-21-4

英文名称

Dolutegravir O-beta-D-Glucuronide

英文化学名

(2S,3S,4S,5R,6S)-6-(((4R,12aS)-9-((2,4-Difluorobenzyl)carbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazin-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid

简化分子线性输入规范(SMILES)

O=C1C(N(C[C@@](OCC2)([H])N1[C@@H]2C)C=C3C(NCC(C=CC(F)=C4)=C4F)=O)=C(C3=O)O[C@@H]([C@@H]([C@H]5O)O)O[C@@H]([C@H]5O)C(O)=O

分子式

C26H27F2N3O11

分子量

595.5

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Dolutegravir O-beta-D-Glucuronide is chemically (2S,3S,4S,5R,6S)-6-(((4R,12aS)-9-((2,4-Difluorobenzyl)carbamoyl)-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazin-7-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid. Dolutegravir O-beta-D-Glucuronide is supplied with detailed characterization data compliant with regulatory guideline. Dolutegravir O-beta-D-Glucuronide can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Dolutegravir. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

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Dolutegravir 杂质 28 CAS号 603999-55-9

基本信息

CAS(化学文摘登记)号

603999-55-9

英文名称

Dolutegravir 杂质 28

英文化学名

2-(2,4-Difluorophenyl)-1-(1H-imidazol-1-yl)ethan-1-one

简化分子线性输入规范(SMILES)

O=C(N1C=NC=C1)CC2=CC=C(F)C=C2F

分子式

C11H8F2N2O

分子量

222.2

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Dolutegravir Impurity 28 is chemically 2-(2,4-Difluorophenyl)-1-(1H-imidazol-1-yl)ethan-1-one. Dolutegravir Impurity 28 is supplied with detailed characterization data compliant with regulatory guideline. Dolutegravir Impurity 28 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Dolutegravir. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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邮箱：chemwhat@watson-int.cn

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ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/dolutegravir-impurity-28-cas-603999-55-9/

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Dolutegravir 杂质 31 CAS号 N/A

基本信息

CAS(化学文摘登记)号

N/A

英文名称

Dolutegravir 杂质 31

英文化学名

(4R,12aR)-7-Ethoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid

简化分子线性输入规范(SMILES)

O=C(C1=CN(C2=C(OCC)C1=O)C[C@@]3([H])OCC[C@@H](C)N3C2=O)O

分子式

C15H18N2O6

分子量

322.3

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Dolutegravir Impurity 31 is chemically (4R,12aR)-7-Ethoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid. Dolutegravir Impurity 31 is supplied with detailed characterization data compliant with regulatory guideline. Dolutegravir Impurity 31 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Dolutegravir. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/dolutegravir-impurity-31-cas-N/A/

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Dolutegravir 杂质 29 CAS号 2315439-81-5

基本信息

CAS(化学文摘登记)号

2315439-81-5

英文名称

Dolutegravir 杂质 29

英文化学名

(4R,12aR)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid

简化分子线性输入规范(SMILES)

O=C(C1=CN(C2=C(OC)C1=O)C[C@@]3([H])OCC[C@@H](C)N3C2=O)O

分子式

C14H16N2O6

分子量

308.3

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Dolutegravir Impurity 29 is chemically (4R,12aR)-7-methoxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid. Dolutegravir Impurity 29 is supplied with detailed characterization data compliant with regulatory guideline. Dolutegravir Impurity 29 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Dolutegravir. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/dolutegravir-impurity-29-cas-2315439-81-5/

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Dolutegravir 杂质 23 CAS号 2384108-28-3

基本信息

CAS(化学文摘登记)号

2384108-28-3

英文名称

Dolutegravir 杂质 23

英文化学名

(4R,12aR)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide

简化分子线性输入规范(SMILES)

O=C(C1=CN(C2=C(OC)C1=O)C[C@@]3([H])OCC[C@@H](C)N3C2=O)NCC4=CC=C(F)C=C4F

分子式

C21H21F2N3O5

分子量

433.4

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Dolutegravir Impurity 23 is chemically (4R,12aR)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide. Dolutegravir Impurity 23 is supplied with detailed characterization data compliant with regulatory guideline. Dolutegravir Impurity 23 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Dolutegravir. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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邮箱：chemwhat@watson-int.cn

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ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/dolutegravir-impurity-23-cas-2384108-28-3/

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Dolutegravir 杂质 25 CAS号 2244161-73-5

基本信息

CAS(化学文摘登记)号

2244161-73-5

英文名称

Dolutegravir 杂质 25

英文化学名

(R)-3-(7-((2,4-difluorobenzyl)carbamoyl)-9-hydroxy-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazin-2-yl)butyl (2,4-difluorobenzyl)carbamate

简化分子线性输入规范(SMILES)

FC1=C(C=CC(F)=C1)CNC(C2=CN(C(C3=O)=C(O)C2=O)C=CN3[C@@H](CCOC(NCC4=C(F)C=C(F)C=C4)=O)C)=O

分子式

C28H24F4N4O6

分子量

588.5

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Dolutegravir Impurity 25 is chemically (R)-3-(7-((2,4-difluorobenzyl)carbamoyl)-9-hydroxy-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazin-2-yl)butyl (2,4-difluorobenzyl)carbamate. Dolutegravir Impurity 25 is supplied with detailed characterization data compliant with regulatory guideline. Dolutegravir Impurity 25 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Dolutegravir. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/dolutegravir-impurity-25-cas-2244161-73-5/

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Dolutegravir 杂质 22 CAS号 1335210-23-5

基本信息

CAS(化学文摘登记)号

1335210-23-5

英文名称

Dolutegravir 杂质 22

英文化学名

1-(2,2-Dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid

简化分子线性输入规范(SMILES)

O=C(OC)C1=C(OC)C(C(C(O)=O)=CN1CC(OC)OC)=O

分子式

C13H17NO8

分子量

315.3

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Dolutegravir Impurity 22 is chemically 1-(2,2-Dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid. Dolutegravir Impurity 22 is supplied with detailed characterization data compliant with regulatory guideline. Dolutegravir Impurity 22 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Dolutegravir. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/dolutegravir-impurity-22-cas-1335210-23-5/

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Desdifluoro Dolutegravir CAS号 2244161-71-3

基本信息

CAS(化学文摘登记)号

2244161-71-3

英文名称

Desdifluoro Dolutegravir

英文化学名

(4R,12aS)-N-Benzyl-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide

简化分子线性输入规范(SMILES)

O=C(C1=CN(C2=C(O)C1=O)C[C@]3([H])OCC[C@@H](C)N3C2=O)NCC4=CC=CC=C4

分子式

C20H21N3O5

分子量

383.4

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Desdifluoro Dolutegravir is chemically (4R,12aS)-N-Benzyl-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide. Desdifluoro Dolutegravir is supplied with detailed characterization data compliant with regulatory guideline. Desdifluoro Dolutegravir can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Dolutegravir. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/desdifluoro-dolutegravir-cas-2244161-71-3/

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Dolutegravir 杂质 27 CAS号 N/A

基本信息

CAS(化学文摘登记)号

N/A

英文名称

Dolutegravir 杂质 27

英文化学名

Sodium (4S,12aR)-9-((4-fluorobenzyl)carbamoyl)-4,12a-dimethyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazin-7-olate

简化分子线性输入规范(SMILES)

O=C(C1=CN2C(C(N([C@@H](C)CCO3)[C@@]3(C)C2)=O)=C([O-])C1=O)NCC4=CC=C(F)C=C4.[Na+]

分子式

C21H21FN3O5 : Na

分子量

414.4 : 23.0

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Dolutegravir Impurity 27 is chemically Sodium (4S,12aR)-9-((4-fluorobenzyl)carbamoyl)-4,12a-dimethyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazin-7-olate. Dolutegravir Impurity 27 is supplied with detailed characterization data compliant with regulatory guideline. Dolutegravir Impurity 27 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Dolutegravir. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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品牌

ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/dolutegravir-impurity-27-cas-N/A/

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