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Afatinib 杂质 23 CAS号 2223677-58-3

基本信息

CAS(化学文摘登记)号

2223677-58-3

英文名称

Afatinib 杂质 23

英文化学名

1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one

简化分子线性输入规范(SMILES)

FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=CC(O[C@H]4CCOC4)=C(N5C(CCC5O)=O)C=C32

分子式

C22H20ClFN4O4

分子量

458.9

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Afatinib Impurity 23 is chemically 1-(4-((3-Chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-5-hydroxypyrrolidin-2-one. Afatinib Impurity 23 is supplied with detailed characterization data compliant with regulatory guideline. Afatinib Impurity 23 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Afatinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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邮箱：chemwhat@watson-int.cn

品牌

ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/afatinib-impurity-23-cas-2223677-58-3/

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Afatinib D6 CAS号 1313874-96-2

基本信息

CAS(化学文摘登记)号

1313874-96-2

英文名称

Afatinib D6

英文化学名

(S,E)-4-(Bis(methyl-d3)amino)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide

简化分子线性输入规范(SMILES)

ClC1=C(F)C=CC(NC2=NC=NC3=C2C=C(NC(/C=C/CN(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)C(O[C@H]4CCOC4)=C3)=C1

分子式

C24H19D6ClFN5O3

分子量

492.0

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Afatinib D6 is chemically (S,E)-4-(Bis(methyl-d3)amino)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide. Afatinib D6 is supplied with detailed characterization data compliant with regulatory guideline. Afatinib D6 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Afatinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

快速询价

邮箱：chemwhat@watson-int.cn

品牌

ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/afatinib-d6-cas-1313874-96-2/

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Afatinib 杂质 22 CAS号 N/A

基本信息

CAS(化学文摘登记)号

N/A

英文名称

Afatinib 杂质 22

英文化学名

N-(3-Chloro-4-fluorophenyl)-N-(6-((E)-4-(dimethylamino)but-2-enamido)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-4-yl)-L-aspartic acid

简化分子线性输入规范(SMILES)

O=C(O)C[C@@H](C(O)=O)N(C1=CC=C(F)C(Cl)=C1)C2=C3C=C(NC(/C=C/CN(C)C)=O)C(O[C@@H]4COCC4)=CC3=NC=N2

分子式

C28H29ClFN5O7

分子量

601.1

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Afatinib Impurity 22 is chemically N-(3-Chloro-4-fluorophenyl)-N-(6-((E)-4-(dimethylamino)but-2-enamido)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-4-yl)-L-aspartic acid. Afatinib Impurity 22 is supplied with detailed characterization data compliant with regulatory guideline. Afatinib Impurity 22 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Afatinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

快速询价

邮箱：chemwhat@watson-int.cn

品牌

ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/afatinib-impurity-22-cas-N/A/

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Afatinib Dimaleate CAS号 850140-73-7

基本信息

CAS(化学文摘登记)号

850140-73-7

英文名称

Afatinib Dimaleate

英文化学名

(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide dimaleate

简化分子线性输入规范(SMILES)

ClC1=C(F)C=CC(NC2=NC=NC3=C2C=C(NC(/C=C/CN(C)C)=O)C(O[C@H]4CCOC4)=C3)=C1.OC(/C=CC(O)=O)=O.OC(/C=CC(O)=O)=O

分子式

C24H25ClFN5O3 : 2(C4H4O4)

分子量

485.9 : 2(116.1)

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Afatinib Dimaleate is chemically (S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide dimaleate. Afatinib Dimaleate is supplied with detailed characterization data compliant with regulatory guideline. Afatinib Dimaleate can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Afatinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

快速询价

邮箱：chemwhat@watson-int.cn

品牌

ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/afatinib-dimaleate-cas-850140-73-7/

相关产品

850140-72-6 (游离碱) ; 1398312-49-6 (盐酸盐) ; 1398312-36-1 (硫酸盐)

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Afatinib D4 CAS号 N/A

基本信息

CAS(化学文摘登记)号

N/A

英文名称

Afatinib D4

英文化学名

(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl-2,2,5,5-d4)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

简化分子线性输入规范(SMILES)

ClC1=C(F)C=CC(NC2=NC=NC3=C2C=C(NC(/C=C/CN(C)C)=O)C(O[C@H]4CC([2H])([2H])OC4([2H])[2H])=C3)=C1

分子式

C24H21D4ClFN5O3

分子量

490.0

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Afatinib D4 is chemically (S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl-2,2,5,5-d4)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide. Afatinib D4 is supplied with detailed characterization data compliant with regulatory guideline. Afatinib D4 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Afatinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

快速询价

邮箱：chemwhat@watson-int.cn

品牌

ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/afatinib-d4-cas-N/A/

相关产品

850140-72-6(Unlabeled)

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Afatinib N-Oxide CAS号 2413212-11-8

基本信息

CAS(化学文摘登记)号

2413212-11-8

英文名称

Afatinib N-Oxide

英文化学名

(S,E)-4-((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-N,N-dimethyl-4-oxobut-2-en-1-amine oxide

简化分子线性输入规范(SMILES)

O=C(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1O[C@@H]4COCC4)/C=C/C[N+](C)([O-])C

分子式

C24H25ClFN5O4

分子量

501.9

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Afatinib N-Oxide is chemically (S,E)-4-((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-N,N-dimethyl-4-oxobut-2-en-1-amine oxide. Afatinib N-Oxide is supplied with detailed characterization data compliant with regulatory guideline. Afatinib N-Oxide can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Afatinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

快速询价

邮箱：chemwhat@watson-int.cn

品牌

ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/afatinib-n-oxide-cas-2413212-11-8/

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Afatinib 杂质 3 CAS号 2475094-96-1

基本信息

CAS(化学文摘登记)号

2475094-96-1

英文名称

Afatinib 杂质 3

英文化学名

N-(4-Chloro-3-fluorophenyl)-7-fluoro-8-nitroquinazolin-4-amine ; (3-Chloro-4-fluorophenyl)(7-fluoro-6-nitroquinazolin-4-yl)amine

简化分子线性输入规范(SMILES)

ClC(C=C1)=C(F)C=C1NC2=NC=NC3=C([N+]([O-])=O)C(F)=CC=C32

分子式

C14H7ClF2N4O2

分子量

336.7

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Afatinib Impurity 3 is chemically N-(4-Chloro-3-fluorophenyl)-7-fluoro-8-nitroquinazolin-4-amine ; (3-Chloro-4-fluorophenyl)(7-fluoro-6-nitroquinazolin-4-yl)amine. Afatinib Impurity 3 is supplied with detailed characterization data compliant with regulatory guideline. Afatinib Impurity 3 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Afatinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

快速询价

邮箱：chemwhat@watson-int.cn

品牌

ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/afatinib-impurity-3-cas-2475094-96-1/

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Afatinib 杂质 10 CAS号 N/A

基本信息

CAS(化学文摘登记)号

N/A

英文名称

Afatinib 杂质 10

英文化学名

(E)-N-(4-((3-Chloro-4-fluorophenyl)(4-((4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-1-(dimethylamino)-4-oxobutan-2-yl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

简化分子线性输入规范(SMILES)

FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=CC(O[C@H]4CCOC4)=C(NC(CC(CN(C)C)N(C5=CC(Cl)=C(F)C=C5)C6=NC=NC7=C6C=C(NC(/C=C/CN(C)C)=O)C(OC8CCOC8)=C7)=O)C=C32

分子式

C48H50Cl2F2N10O6

分子量

971.9

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Afatinib Impurity 10 is chemically (E)-N-(4-((3-Chloro-4-fluorophenyl)(4-((4-((3-chloro-4-fluorophenyl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-1-(dimethylamino)-4-oxobutan-2-yl)amino)-7-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide. Afatinib Impurity 10 is supplied with detailed characterization data compliant with regulatory guideline. Afatinib Impurity 10 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Afatinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

快速询价

邮箱：chemwhat@watson-int.cn

品牌

ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/afatinib-impurity-10-cas-N/A/

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Afatinib 杂质 12 CAS号 2121530-37-6

基本信息

CAS(化学文摘登记)号

2121530-37-6

英文名称

Afatinib 杂质 12

英文化学名

(S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-hydroxybut-2-enamide

简化分子线性输入规范(SMILES)

FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=CC(O[C@H]4CCOC4)=C(NC(/C=C/CO)=O)C=C32

分子式

C22H20ClFN4O4

分子量

458.9

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Afatinib Impurity 12 is chemically (S,E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-hydroxybut-2-enamide. It is also known as 4-Hydroxy 4-Dedimethylamino Afatinib. Afatinib Impurity 12 is supplied with detailed characterization data compliant with regulatory guideline. Afatinib Impurity 12 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Afatinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

快速询价

邮箱：chemwhat@watson-int.cn

品牌

ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/afatinib-impurity-12-cas-2121530-37-6/

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Afatinib 杂质 H CAS号 2223677-64-1

基本信息

CAS(化学文摘登记)号

2223677-64-1

英文名称

Afatinib 杂质 H

英文化学名

(S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide

简化分子线性输入规范(SMILES)

FC1=C(Cl)C=C(NC2=NC=NC3=C2C=C(NC(/C=C/C)=O)C(O[C@H]4CCOC4)=C3)C=C1

分子式

C22H20ClFN4O3

分子量

442.9

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Afatinib Impurity H is chemically (S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide. Afatinib Impurity H is supplied with detailed characterization data compliant with regulatory guideline. Afatinib Impurity H can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Afatinib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

快速询价

邮箱：chemwhat@watson-int.cn

品牌

ChemWhat（凯望）—— 品牌介绍

ChemWhat官网链接地址

https://www.chemwhat.com/afatinib-impurity-h-cas-2223677-64-1/

相关产品

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