• 基本信息
• 物理性质
• 安全信息
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基本信息

CAS(化学文摘登记)号

N/A

英文名称

Abemaciclib 杂质 15

英文化学名

N,N’-((piperazine-1,4-diylbis(methylene))bis(pyridine-5,2-diyl))bis(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine)

简化分子线性输入规范(SMILES)

FC1=C2C(N(C(C)C)C(C)=N2)=CC(C3=C(F)C=NC(NC4=CC=C(CN5CCN(CC6=CC=C(NC7=NC(C8=CC(F)=C(N=C(C)N9C(C)C)C9=C8)=C(F)C=N7)N=C6)CC5)C=N4)=N3)=C1

分子式

C46H46F4N14

分子量

871.0

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Abemaciclib Impurity 15 is chemically N,N’-((piperazine-1,4-diylbis(methylene))bis(pyridine-5,2-diyl))bis(5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-amine). Abemaciclib Impurity 15 is supplied with detailed characterization data compliant with regulatory guideline. Abemaciclib Impurity 15 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Abemaciclib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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• 基本信息
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• 详细规格
• 快速询价及关联信息

基本信息

CAS(化学文摘登记)号

N/A

英文名称

Abemaciclib Nitroso 杂质 3

英文化学名

1-((6-Bromopyridin-3-yl)methyl)-4-nitrosopiperazine

简化分子线性输入规范(SMILES)

O=NN1CCN(CC2=CC=C(Br)N=C2)CC1

分子式

C10H13BrN4O

分子量

285.1

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Abemaciclib Nitroso Impurity 3 is chemically 1-((6-Bromopyridin-3-yl)methyl)-4-nitrosopiperazine. Abemaciclib Nitroso Impurity 3 is supplied with detailed characterization data compliant with regulatory guideline. Abemaciclib Nitroso Impurity 3 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Abemaciclib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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基本信息

CAS(化学文摘登记)号

1231930-37-2

英文名称

Abemaciclib 杂质 10

英文化学名

4-Fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole

简化分子线性输入规范(SMILES)

FC1=CC(B2OC(C)(C(C)(C)O2)C)=CC3=C1N=C(C)N3C(C)C

分子式

C17H24BFN2O2

分子量

318.2

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Abemaciclib Impurity 10 is chemically 4-Fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole. Abemaciclib Impurity 10 is supplied with detailed characterization data compliant with regulatory guideline. Abemaciclib Impurity 10 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Abemaciclib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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ChemWhat（凯望）—— 品牌介绍

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基本信息

CAS(化学文摘登记)号

2138499-06-4

英文名称

​2-​Methanol Abemaciclib

英文化学名

(6-(2-((5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)amino)-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-1H-benzo[d]imidazol-2-yl)methanol

简化分子线性输入规范(SMILES)

CC(N1C2=CC(C3=NC(NC(N=C4)=CC=C4CN(CC5)CCN5CC)=NC=C3F)=CC(F)=C2N=C1CO)C

分子式

C27H32F2N8O

分子量

522.6

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

​2-​Methanol Abemaciclib is chemically (6-(2-((5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-yl)amino)-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-1H-benzo[d]imidazol-2-yl)methanol. ​2-​Methanol Abemaciclib is supplied with detailed characterization data compliant with regulatory guideline. ​2-​Methanol Abemaciclib can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Abemaciclib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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https://www.chemwhat.com/2-methanolabemaciclib-cas-2138499-06-4/

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基本信息

CAS(化学文摘登记)号

1231930-57-6

英文名称

Abemaciclib Metabolites M2

英文化学名

5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(5-(piperazin-1-ylmethyl)pyridin-2-yl)pyrimidin-2-amine

简化分子线性输入规范(SMILES)

CC(N1C2=CC(C3=NC(NC4=CC=C(CN5CCNCC5)C=N4)=NC=C3F)=CC(F)=C2N=C1C)C

分子式

C25H28F2N8

分子量

478.6

物理性质

外观

安全信息

危险品运输编号

非危险品

德国水污染物质分类清单(WGK Germany)

3

详细规格

测试方法

核磁；质谱，液相色谱

保存条件

常温避光保存

产品描述

Abemaciclib Metabolites M2 is chemically 5-Fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)-N-(5-(piperazin-1-ylmethyl)pyridin-2-yl)pyrimidin-2-amine. Abemaciclib Metabolites M2 is supplied with detailed characterization data compliant with regulatory guideline. Abemaciclib Metabolites M2 can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Abemaciclib. The product can be used as reference standards and further traceability against pharmacopeial standards (USP or EP) can be provided based on feasibility. ChemWhat products are for analytical purpose only and not for human use.

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2139329-63-6 (TFA salt)